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Miri Goldin

TAU Post Doc

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Address

  • School of Physics and Astronomy, Tel Aviv University
  • Tel Aviv
  • 69978
  • Israel

Contact

  • This email address is being protected from spambots. You need JavaScript enabled to view it.
  • +00972 (0)3 6405637

Miscellaneous Information

Research Highlights

Rehavi M. Goldin M, Roz N and Weizman A. Regulation of rat brain vesicular monoamine transporter by chronic treatment with ovarian hormones. Brain Research. 57(1): 31-37 (1998).

Goldin M. Segal M and Avignone E. Functional Plasticity Triggers Formation and Pruning of Dendritic Spines in Cultured Hippocampal Networks. J Neurosci. 21: 186-193 (2001).

Goldin M. Segal M. Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons. Eur J Neurosci. 17(12): 2529-39 (2003).

Goldin M. Epsztein J. Jorquera I. Represa A. Ben-Ari Y. Crepel V. and Cossart R. Synaptic Kainate Receptors Tune Oriens-Lacunosum Moleculare Interneurons to Operate at Theta Frequency. J Neurosci. 27: 9560-9572 (2007).

Ovtscharoff W. Segal M. Goldin M. Helmeke C. Kreher U. Greenberger V. Herzog A. MichaelisB and Braun K. Electron microscopic 3D-reconstruction of dendritic spines in cultured hippocampal neurons undergoing synaptic plasticity. Developmental NeurobiologyPublished Online: 7 Mar 2008.

Bonifazi P. 1, Goldin M. 1, Picardo M., Jorquera I., Bianconi G., Represa A., Ben-Ari Y. and Cossart R. GABAergic hub neurons orchestrate synchrony in developing hippocampal networks. Science 2009 Dec 4;326(5958):1419-24 (1 P. Bonifazi and M. Goldin equally contributed to the work).

Meshulam L, Galron R, Kanner S, De Pitta' M, Bonifazi P, Goldin M, Frenkel D, Ben-Jacob E, Barzilai A. The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia. Front Pharmacol. 2012;3:157. doi: 10.3389/fphar.2012.00157. Epub 2012 Sep 17.

Bonifazi P, Goldin M, Galron R, Kanner S, Herzog N, Hanein Y, Barzilai A and Ben-Jacob E. Engineering chimera neuron-glia networks: a testing arena for brain circuit repair. Under revision.

Bonifazi P, Difato F, Breschi GL, Massobrio P, Levi T, Goldin M, Pasquale V, Tessadori J, Bisio M, Bornat Y, Taverna S and Chiappalone M. In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses. Under revision.

Research Interests

One of the main challenges of modern neuroscience is to understand how network dynamics are related to anatomical connectivity. Recently, it has been demonstrated the existence of functional connector “hubs” in the developing hippocampus where such a function is met by a heterogeneous subpopulation of pioneer GABAergic interneurons that display widespread axonal projections. GABAergic hub cells play a central role in the coordination of early network synchronizations combining high functional, effective and structural connectivity. Are hub neurons common components of all growing neuronal networks or other mechanisms/topologies emerge? We try to address this question in finite-size neuronal networks grown in culture which may represent a general model of self-organized neuronal circuits not depending on a specific architecture. Concerning neurodegenerative disorders, we aim at identifying impaired circuit dynamics in cerebellar networks extracted from murine models of the human genetic disease Ataxia Telangiectasia (A-T) with special focus on the contribution of glia cells on neuronal dynamics.

Most relevant publications

Bonifazi P. 1, Goldin M. 1, Picardo M., Jorquera I., Bianconi G., Represa A., Ben-Ari Y. and Cossart R. GABAergic hub neurons orchestrate synchrony in developing hippocampal networks. Science 2009 Dec 4;326(5958):1419-24 (1 P. Bonifazi and M. Goldin equally contributed to the work).

Meshulam L, Galron R, Kanner S, De Pitta' M, Bonifazi P, Goldin M, Frenkel D, Ben-Jacob E, Barzilai A. The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia. Front Pharmacol. 2012;3:157. doi: 10.3389/fphar.2012.00157. Epub 2012 Sep 17.

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The BrainBow project acknowledges the financial support of the Future and Emerging Technologies (FET) programme within the Seventh Framework Programme for Research of the European Commission, under FET-Open grant number: FP7-284772.

Fundings1